Aziza Khudoiberdiyeva, a doctoral student at Samarkand State University, conducts research on the importance of synthesis of biologically active substances in the production of anticancer drugs.

    Aziza Khudoiberdiyeva, a doctoral student at the Department of Organic Synthesis and Organic Chemistry of Samarkand State University, is conducting research on the topic "Synthesis of alkaloids of the isochenolin type based on dibasic carboxylic acids." The main essence of research is the synthesis of biologically active substances by a synthetic method.

    Biologically active substances are currently being studied in the fields of biochemistry, bioorganic chemistry and pharmaceuticals. These are compounds with special physicochemical properties that have a positive effect on the cells of the body, restoring the function of damaged cells. These substances are found mainly in plants. Until recently, biological substances necessary for the production of drugs in the field of pharmacology were obtained naturally from plants. This required a lot of effort and expense. In addition, a sharp reduction in plants in nature has led to the extinction of rare species. Therefore, the need for the synthesis of biologically active substances necessary for the pharmaceutical industry is increasing, and synthetic synthesis will be introduced. This research is important because it is based on a synthetic method of synthesizing chemicals.

    “Synthetic methods for the synthesis of biological substances are as effective as natural ones,” says researcher Aziza Khudoiberdiyeva. In our study, biologically active substances are synthesized synthetically in the laboratory and their pharmacological properties are tested. Depending on the characteristics of the medicine, it is intended for human consumption. It is noteworthy that such substances have a selective effect. That is, when they are introduced into the body as a medicine, they only affect damaged cells without affecting healthy cells. Recently, the Agency for Intellectual Property of the Republic of Uzbekistan patented a chemical substance with selective cytotoxic activity, synthesized in our experiments with the staff of the department under the guidance of Associate Professor of the Department of Organic Synthesis Abdusalom Saidov. This tool is used in pharmacology, medicine. Its main function is to fight cancer cells by reducing the harmful effects on healthy liver cells. The level of activity of this substance is much higher than that of cisplatin used in Indian pharmaceuticals.

    Aziza Khudoiberdieva, a follower of the Scientific School of Synthesis of Biologically Active Substances, founded by Associate Professor Munavvar Alimova at Samarkand State University, is conducting research on the research topic together with the Institute of Plant Chemistry of the Russian Academy of Sciences. To date, about 10 scientific articles have been published in international journals and more than 20 in national scientific journals. The researcher also teaches students the basics of chemistry in English.

Iroda Bekmurodova,

Samarkand State University

News office.

Photos by Shavkat Akramov.